Title : Activation of the RalGEF/Ral pathway promotes prostate cancer metastasis to bone.

Pub. Date : 2007 Nov

PMID : 17709381






1 Functional Relationships(s)
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1 Three effector pathways downstream of Ras, Raf/extracellular signal-regulated kinase (ERK), phosphatidylinositol 3-kinase, and Ral guanine nucleotide exchange factors (RalGEFs), were assayed for their ability to promote the metastasis of a tumorigenic, nonmetastatic human prostate cancer cell line, DU145. Guanine Nucleotides RAS like proto-oncogene A Homo sapiens