Title : Effect of commonly used organic solvents on the kinetics of cytochrome P450 2B6- and 2C8-dependent activity in human liver microsomes.

Pub. Date : 2007 Nov

PMID : 17709370






1 Functional Relationships(s)
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1 Acetonitrile, DMSO, and ethanol were shown to increase the Km and decrease the intrinsic clearance (CLint) of CYP2B6-mediated bupropion hydroxylation in a concentration-dependent manner. Ethanol cytochrome P450 family 2 subfamily B member 6 Homo sapiens