Title : Molecular determinants of Pb2+ interaction with NMDA receptor channels.

Pub. Date : 2008 Jan

PMID : 17706324






1 Functional Relationships(s)
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1 Although none of the mutations that we have tested abolished the block by Pb2+, our results indicate that the action of this toxic metal on NR channels is more dependent on the receptor composition than previously thought, because Zn2+ is able to displace Pb2+ from its binding site in epsilon1-containing channels, but not in epsilon2-containing channels. Zinc glutamate ionotropic receptor NMDA type subunit 1 L homeolog Xenopus laevis