Title : Activation of mammalian target of rapamycin complex 1 and insulin resistance induced by palmitate in hepatocytes.

Pub. Date : 2007 Oct 12

PMID : 17698034






1 Functional Relationships(s)
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1 Metformin treatment of the hepatocytes resulted in activation of the AMP-activated kinase, attenuation of the mTOR/S6K1 pathway, reduction of IRS-1 phosphorylation, and a leftward shift in the insulin dose-response curve for PKB activation. Metformin insulin receptor substrate 1 Homo sapiens