Title : Reduced tumor growth in vivo and increased c-Abl activity in PC3 prostate cancer cells overexpressing the Shb adapter protein.

Pub. Date : 2007 Aug 15

PMID : 17697368






2 Functional Relationships(s)
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Protein Name
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1 RESULTS: PC3 cells overexpressing Shb exhibited increased rates of apoptosis in the presence of the anti-tumor agent 2-ME. 2-Methoxyestradiol SH2 domain containing adaptor protein B Homo sapiens
2 CONCLUSION: It is concluded that Shb promotes 2-ME-induced PC3 cell apoptosis by increased pro-apoptotic signaling via the c-Abl pathway and that this causes reduced tumor growth in vivo. 2-Methoxyestradiol SH2 domain containing adaptor protein B Homo sapiens