Title : The group VIA calcium-independent phospholipase A2 participates in ER stress-induced INS-1 insulinoma cell apoptosis by promoting ceramide generation via hydrolysis of sphingomyelins by neutral sphingomyelinase.

Pub. Date : 2007 Sep 4

PMID : 17685585






3 Functional Relationships(s)
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1 We previously reported that apoptosis of INS-1 insulinoma cells due to thapsigargin-induced ER stress was suppressed by inhibition of the group VIA Ca2+-independent phospholipase A2 (iPLA2beta), associated with an increased level of ceramide generation, and that the effects of ER stress were amplified in INS-1 cells in which iPLA2beta was overexpressed (OE INS-1 cells). Ceramides insulin 1 Rattus norvegicus
2 These findings suggested that iPLA2beta and ceramides participate in ER stress-induced INS-1 cell apoptosis. Ceramides insulin 1 Rattus norvegicus
3 These findings indicate that iPLA2beta activation participates in ER stress-induced INS-1 cell apoptosis by promoting ceramide generation via NSMase-catalyzed hydrolysis of sphingomyelins, raising the possibility that this pathway contributes to beta-cell apoptosis due to ER stress. Ceramides insulin 1 Rattus norvegicus