Title : Involvement of VIP and PACAP in neonatal brain lesions generated by a combined excitotoxic/inflammatory challenge.

Pub. Date : 2007 Sep

PMID : 17683829






2 Functional Relationships(s)
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1 We further tested whether the intraperitoneal injection of IL-1beta, known to aggravate the ibotenate-induced lesions, could modify the expression pattern of VIP-related genes. Ibotenic Acid interleukin 1 beta Homo sapiens
2 Finally, we concluded using histological analysis that VIP[ala(11,22,28)], a synthetic VPAC(1) agonist completely reversed the aggravating effects of IL-1beta on ibotenate-induced lesions of the periventricular white matter. Ibotenic Acid interleukin 1 beta Homo sapiens