Title : BRCA1- and BRCA2-deficient cells are sensitive to etoposide-induced DNA double-strand breaks via topoisomerase II.

Pub. Date : 2007 Aug 1

PMID : 17671173






1 Functional Relationships(s)
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1 Previously, both BRCA1- and BRCA2-deficient tumors were shown to be sensitive to mitomycin C, and the mechanism was presumed to be a defect in the repair of interstrand crosslinks by homologous recombination. Mitomycin BRCA1 DNA repair associated Homo sapiens