Title : Chronic glucocorticoids increase hippocampal vulnerability to neurotoxicity under conditions that produce CA3 dendritic retraction but fail to impair spatial recognition memory.

Pub. Date : 2007 Aug 1

PMID : 17670974






8 Functional Relationships(s)
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1 We previously found that chronic stress conditions producing CA3 dendritic retraction and spatial memory deficits make the hippocampus vulnerable to the neurotoxin ibotenic acid (IBO). Ibotenic Acid carbonic anhydrase 3 Rattus norvegicus
2 We previously found that chronic stress conditions producing CA3 dendritic retraction and spatial memory deficits make the hippocampus vulnerable to the neurotoxin ibotenic acid (IBO). Ibotenic Acid carbonic anhydrase 3 Rattus norvegicus
3 The purpose of this study was to determine whether exposure to chronic corticosterone (CORT) under conditions that produce CA3 dendritic retraction would enhance CA3 susceptibility to IBO. Ibotenic Acid carbonic anhydrase 3 Rattus norvegicus
4 The purpose of this study was to determine whether exposure to chronic corticosterone (CORT) under conditions that produce CA3 dendritic retraction would enhance CA3 susceptibility to IBO. Ibotenic Acid carbonic anhydrase 3 Rattus norvegicus
5 Three days after treatments stopped, IBO was infused into the CA3 region. Ibotenic Acid carbonic anhydrase 3 Rattus norvegicus
6 Conditions producing CA3 dendritic retraction (CORT and vehicle) exacerbated IBO-induced CA3 damage compared with conditions in which CA3 dendritic retraction was not observed (vehicle and vehicle, vehicle and phenytoin, CORT and phenytoin). Ibotenic Acid carbonic anhydrase 3 Rattus norvegicus
7 Conditions producing CA3 dendritic retraction (CORT and vehicle) exacerbated IBO-induced CA3 damage compared with conditions in which CA3 dendritic retraction was not observed (vehicle and vehicle, vehicle and phenytoin, CORT and phenytoin). Ibotenic Acid carbonic anhydrase 3 Rattus norvegicus
8 Conditions producing CA3 dendritic retraction (CORT and vehicle) exacerbated IBO-induced CA3 damage compared with conditions in which CA3 dendritic retraction was not observed (vehicle and vehicle, vehicle and phenytoin, CORT and phenytoin). Ibotenic Acid carbonic anhydrase 3 Rattus norvegicus