Title : Fenretinide corrects newly found ceramide deficiency in cystic fibrosis.

Pub. Date : 2008 Jan

PMID : 17656682






2 Functional Relationships(s)
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1 Since it has been previously reported that in vitro treatment with fenretinide induced ceramide in neuroblastoma cell lines, we decided to test this drug in vivo using our Cftr-knockout mice in an attempt to correct this newly identified defect in ceramide levels. Fenretinide cystic fibrosis transmembrane conductance regulator Mus musculus
2 We further assessed the biological effect of fenretinide on the ability of Cftr-knockout mice to combat lung infection with P. aeruginosa. Fenretinide cystic fibrosis transmembrane conductance regulator Mus musculus