Title : Blockade of sonic hedgehog signal pathway enhances antiproliferative effect of EGFR inhibitor in pancreatic cancer cells.

Pub. Date : 2007 Aug

PMID : 17640486






1 Functional Relationships(s)
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1 AIM: To investigate the expression of sonic hedgehog (SHH) and epidermal growth factor receptor (EGFR) signal molecules in pancreatic cancer cells, and to assess the inhibitory effects through the blockade of the SHH and EGFR signaling pathways by cyclopamine and Iressa, respectively. Gefitinib sonic hedgehog signaling molecule Homo sapiens