Title : Critical roles of residues 36 and 40 in the phenol and tertiary amine aglycone substrate selectivities of UDP-glucuronosyltransferases 1A3 and 1A4.

Pub. Date : 2007 Oct

PMID : 17636046






2 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 UGT1A3 glucuronidates the planar phenols 1-naphthol (1-NP) and 4-methylumbelliferone (4-MU), whereas UGT1A4 converts the tertiary amines lamotrigine (LTG) and trifluoperazine (TFP) to quaternary ammonium glucuronides. Lamotrigine UDP glucuronosyltransferase family 1 member A4 Homo sapiens
2 UGT1A3 glucuronidates the planar phenols 1-naphthol (1-NP) and 4-methylumbelliferone (4-MU), whereas UGT1A4 converts the tertiary amines lamotrigine (LTG) and trifluoperazine (TFP) to quaternary ammonium glucuronides. Lamotrigine UDP glucuronosyltransferase family 1 member A4 Homo sapiens