Title : Structural basis for UBA-mediated dimerization of c-Cbl ubiquitin ligase.

Pub. Date : 2007 Sep 14

PMID : 17635922






1 Functional Relationships(s)
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1 Both c-Cbl and Cbl-b contain a ubiquitin-associated (UBA) domain, which is important for Cbl dimerization and tyrosine phosphorylation; however, the mechanism of UBA-mediated dimerization and its requirement for Cbl biological activity is unclear. UBP 310 Cbl proto-oncogene B Homo sapiens