Title : Transforming growth factor beta1-regulated xylosyltransferase I activity in human cardiac fibroblasts and its impact for myocardial remodeling.

Pub. Date : 2007 Sep 7

PMID : 17635914






4 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 For XT-I we found an increased expression in parallel with an elevated chondroitin sulfate-GAG content after incubation with TGF-beta(1) and after mechanical stretch. Glycosaminoglycans xylosyltransferase 1 Homo sapiens
2 Usage of XT-I small interfering RNA could specifically block the increased XT-I expression under mechanical stress and resulted in a significantly reduced chondroitin sulfate-GAG content. Glycosaminoglycans xylosyltransferase 1 Homo sapiens
3 Specific blocking of XT-I expression confirmed that XT-I catalyzes a rate-limiting step during fibrotic GAG biosynthesis. Glycosaminoglycans xylosyltransferase 1 Homo sapiens
4 Specific blocking of XT-I expression confirmed that XT-I catalyzes a rate-limiting step during fibrotic GAG biosynthesis. Glycosaminoglycans xylosyltransferase 1 Homo sapiens