Pub. Date : 2007
PMID : 17622767
7 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Histamine induces MUC5AC expression via a hCLCA1 pathway. | Histamine | mucin 5AC, oligomeric mucus/gel-forming | Homo sapiens |
| 2 | OBJECTIVE: The aim of this study is to investigate whether histamine induces MUC5AC production in NCI-H292 cells, and to evaluate which pathway is involved in this mucin production. | Histamine | mucin 5AC, oligomeric mucus/gel-forming | Homo sapiens |
| 3 | RESULTS: Histamine upregulated MUC5AC gene expression and mucin protein production in a dose-dependent and time-related fashion. | Histamine | mucin 5AC, oligomeric mucus/gel-forming | Homo sapiens |
| 4 | Moreover, pretreatment of cells with chlorpheniramine or NFA reduced histamine-induced MUC5AC mRNA expression and protein production in these cells. | Histamine | mucin 5AC, oligomeric mucus/gel-forming | Homo sapiens |
| 5 | The histamine-treated cells showed increased cytoplasmic staining for MUC5AC compared to cells treated with media alone, and cells pretreated with chlorpheniramine or NFA before histamine treatment. | Histamine | mucin 5AC, oligomeric mucus/gel-forming | Homo sapiens |
| 6 | CONCLUSION: Our results suggest that histamine-induced MUC5AC production occurs via the upregulation of hCLCA1. | Histamine | mucin 5AC, oligomeric mucus/gel-forming | Homo sapiens |
| 7 | It is assumed that antihistamines or hCLCA1 channel blockers can partially suppress histamine-induced MUC5AC production in allergic diseases, e.g. allergic rhinitis. | Histamine | mucin 5AC, oligomeric mucus/gel-forming | Homo sapiens |