Title : EGFR activation results in enhanced cyclooxygenase-2 expression through p38 mitogen-activated protein kinase-dependent activation of the Sp1/Sp3 transcription factors in human gliomas.

Pub. Date : 2007 Jul 1

PMID : 17616668






1 Functional Relationships(s)
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1 Finally, treatment of glioma cell lines with prostaglandin E2, the predominant product of COX-2 activity, results in increased vascular endothelial growth factor expression, thus potentially linking elevations in COX-2 expression with tumor angiogenesis in malignant gliomas. Dinoprostone vascular endothelial growth factor A Homo sapiens