Title : TNF but not IL-1 in dogs causes lethal lung injury and multiple organ dysfunction similar to human sepsis.

Pub. Date : 1991 Nov

PMID : 1761500






3 Functional Relationships(s)
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1 Animals given TNF had early (0-4 h) decreases (P less than 0.05) in arterial PO2, increases (P less than 0.05) in physiological shunt fraction and alveolar-to-arterial PO2 gradient, and a high mortality rate (50%). PO-2 tumor necrosis factor Homo sapiens
2 Animals given TNF had early (0-4 h) decreases (P less than 0.05) in arterial PO2, increases (P less than 0.05) in physiological shunt fraction and alveolar-to-arterial PO2 gradient, and a high mortality rate (50%). PO-2 tumor necrosis factor Homo sapiens
3 Animals challenged with TNF and not IL-1 had reversible depression of LVEF similar in time course to abnormalities in arterial PO2. PO-2 tumor necrosis factor Homo sapiens