Title : Phosphorylated PKR contributes the induction of GRP94 under ER stress.

Pub. Date : 2007 Aug 31

PMID : 17612505






2 Functional Relationships(s)
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1 To resolve this issue, we employed a PKR inhibitor together with ER stress inducers (tunicamycin, thapsigargin, and 2-deoxyglucose) and found that this treatment applied to SK-N-SH and HepG2 cells suppressed the expressional induction of 94kDa glucose regulated protein (GRP94) but not GRP78 proteins at both protein and mRNA levels. Deoxyglucose heat shock protein 90 beta family member 1 Homo sapiens
2 To resolve this issue, we employed a PKR inhibitor together with ER stress inducers (tunicamycin, thapsigargin, and 2-deoxyglucose) and found that this treatment applied to SK-N-SH and HepG2 cells suppressed the expressional induction of 94kDa glucose regulated protein (GRP94) but not GRP78 proteins at both protein and mRNA levels. Deoxyglucose heat shock protein 90 beta family member 1 Homo sapiens