Pub. Date : 2007 Jul
PMID : 17609585
7 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Irinotecan activates p53 with its active metabolite, resulting in human hepatocellular carcinoma apoptosis. | Irinotecan | tumor protein p53 | Homo sapiens |
| 2 | SN-38 significantly increased the expression of p53 protein and its phosphorylation at Ser(15) in the nucleus and apoptosis-inducing proteins Bax, caspase-9, and caspase-3, while it significantly decreased the antiapoptosis protein Bcl-xL of Huh7 cells. | Irinotecan | tumor protein p53 | Homo sapiens |
| 3 | SN-38-induced apoptosis was recovered after p53 antisense oligodeoxynucleotide (AS ODN) pretreatment, while Huh7 cells were precultured with p53 AS ODN, followed by the addition of SN-38 for 24 h. Furthermore, increases in p53 DNA-binding activity were observed in the nuclei of Huh7 cells after SN-38 treatment as shown by electrophoretic mobility shift analysis. | Irinotecan | tumor protein p53 | Homo sapiens |
| 4 | SN-38-induced apoptosis was recovered after p53 antisense oligodeoxynucleotide (AS ODN) pretreatment, while Huh7 cells were precultured with p53 AS ODN, followed by the addition of SN-38 for 24 h. Furthermore, increases in p53 DNA-binding activity were observed in the nuclei of Huh7 cells after SN-38 treatment as shown by electrophoretic mobility shift analysis. | Irinotecan | tumor protein p53 | Homo sapiens |
| 5 | SN-38-induced apoptosis was recovered after p53 antisense oligodeoxynucleotide (AS ODN) pretreatment, while Huh7 cells were precultured with p53 AS ODN, followed by the addition of SN-38 for 24 h. Furthermore, increases in p53 DNA-binding activity were observed in the nuclei of Huh7 cells after SN-38 treatment as shown by electrophoretic mobility shift analysis. | Irinotecan | tumor protein p53 | Homo sapiens |
| 6 | SN-38 binding motifs were detected in the proximal promoter of p53 (bases -433 to -317 and -814 to -711). | Irinotecan | tumor protein p53 | Homo sapiens |
| 7 | These results suggest that the p53-mediated apoptosis pathway is important in the anticancer effects of irinotecan in hepatocellular carcinoma. | Irinotecan | tumor protein p53 | Homo sapiens |