Title : Identification of functional polymorphisms in the promoter region of the human PICK1 gene and their association with methamphetamine psychosis.

Pub. Date : 2007 Jul

PMID : 17606663






9 Functional Relationships(s)
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1 Identification of functional polymorphisms in the promoter region of the human PICK1 gene and their association with methamphetamine psychosis. Methamphetamine protein interacting with PRKCA 1 Homo sapiens
2 OBJECTIVE: Protein interacting with C-kinase-1 (PICK1) plays a role in the targeting and clustering of dopamine transporter, which is the primary target site for the abused drug methamphetamine. Methamphetamine protein interacting with PRKCA 1 Homo sapiens
3 OBJECTIVE: Protein interacting with C-kinase-1 (PICK1) plays a role in the targeting and clustering of dopamine transporter, which is the primary target site for the abused drug methamphetamine. Methamphetamine protein interacting with PRKCA 1 Homo sapiens
4 Based on the interaction of PICK1 with dopamine transporter, it is of particular interest to investigate the association between the PICK1 gene and methamphetamine abusers. Methamphetamine protein interacting with PRKCA 1 Homo sapiens
5 METHOD: The authors studied the association between PICK1 gene polymorphisms and methamphetamine abusers in a Japanese group. Methamphetamine protein interacting with PRKCA 1 Homo sapiens
6 CONCLUSIONS: Our findings suggest that the PICK1 gene may be implicated in the susceptibility to spontaneous relapse of methamphetamine psychosis and that, as an intracellular adapter protein, PICK1 may play a role in the pathophysiology of methamphetamine psychosis. Methamphetamine protein interacting with PRKCA 1 Homo sapiens
7 CONCLUSIONS: Our findings suggest that the PICK1 gene may be implicated in the susceptibility to spontaneous relapse of methamphetamine psychosis and that, as an intracellular adapter protein, PICK1 may play a role in the pathophysiology of methamphetamine psychosis. Methamphetamine protein interacting with PRKCA 1 Homo sapiens
8 CONCLUSIONS: Our findings suggest that the PICK1 gene may be implicated in the susceptibility to spontaneous relapse of methamphetamine psychosis and that, as an intracellular adapter protein, PICK1 may play a role in the pathophysiology of methamphetamine psychosis. Methamphetamine protein interacting with PRKCA 1 Homo sapiens
9 CONCLUSIONS: Our findings suggest that the PICK1 gene may be implicated in the susceptibility to spontaneous relapse of methamphetamine psychosis and that, as an intracellular adapter protein, PICK1 may play a role in the pathophysiology of methamphetamine psychosis. Methamphetamine protein interacting with PRKCA 1 Homo sapiens