Title : The interactive effect of methyl-group diet and polymorphism of methylenetetrahydrofolate reductase on the risk of colorectal cancer.

Pub. Date : 2007 Sep 1

PMID : 17602711






2 Functional Relationships(s)
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1 The protective effect of the homozygous variant TT form of the MTHFR genotype (C677T) on the risk of colorectal cancer seems to be modified by the level of methyl diets, that is, by folate, which has a protective effect, or conversely by alcohol. Alcohols methylenetetrahydrofolate reductase Homo sapiens
2 Recommendation of higher intake of folate and lower intake of alcohol to the target population, especially those with TT genotype of MTHFR, may be an effective preventive approach against colorectal cancer. Alcohols methylenetetrahydrofolate reductase Homo sapiens