Pub. Date : 2007 Dec
PMID : 17597824
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | A potential role for the phospholipase D2-aquaporin-3 signaling module in early keratinocyte differentiation: production of a phosphatidylglycerol signaling lipid. | Phosphatidylglycerols | aquaporin 3 (Gill blood group) | Homo sapiens |
| 2 | As PLD2 can utilize the physiological alcohol glycerol to form phosphatidylglycerol (PG), we hypothesized that AQP3 provides glycerol to PLD2 for PG synthesis, which then modulates keratinocyte function. | Phosphatidylglycerols | aquaporin 3 (Gill blood group) | Homo sapiens |
| 3 | As PLD2 can utilize the physiological alcohol glycerol to form phosphatidylglycerol (PG), we hypothesized that AQP3 provides glycerol to PLD2 for PG synthesis, which then modulates keratinocyte function. | Phosphatidylglycerols | aquaporin 3 (Gill blood group) | Homo sapiens |
| 4 | As PLD2 can utilize the physiological alcohol glycerol to form phosphatidylglycerol (PG), we hypothesized that AQP3 provides glycerol to PLD2 for PG synthesis, which then modulates keratinocyte function. | Phosphatidylglycerols | aquaporin 3 (Gill blood group) | Homo sapiens |
| 5 | Acidic medium inhibits AQP3 transport activity; both glycerol uptake and PG synthesis were inhibited by low versus physiological pH. | Phosphatidylglycerols | aquaporin 3 (Gill blood group) | Homo sapiens |
| 6 | Thus, our results support the idea that AQP3 supplies PLD2 with glycerol for synthesizing PG, a lipid signal that promotes early keratinocyte differentiation. | Phosphatidylglycerols | aquaporin 3 (Gill blood group) | Homo sapiens |