Pub. Date : 2007 Nov
PMID : 17590492
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Treatment of the mice with kahweol and cafestol also resulted in a significant decrease in the cytochrome P450 2E1 (CYP2E1), the major isozyme involved in CCl(4) bioactivation, specific enzyme activities, such as p-nitrophenol and aniline hydroxylation. | cafestol | cytochrome P450, family 2, subfamily e, polypeptide 1 | Mus musculus |
| 2 | Treatment of the mice with kahweol and cafestol also resulted in a significant decrease in the cytochrome P450 2E1 (CYP2E1), the major isozyme involved in CCl(4) bioactivation, specific enzyme activities, such as p-nitrophenol and aniline hydroxylation. | cafestol | cytochrome P450, family 2, subfamily e, polypeptide 1 | Mus musculus |
| 3 | These results suggest that the protective effects of kahweol and cafestol against the CCl(4)-induced hepatotoxicity possibly involve mechanisms related to their ability to block the CYP2E1-mediated CCl(4) bioactivation and free radical scavenging effects. | cafestol | cytochrome P450, family 2, subfamily e, polypeptide 1 | Mus musculus |