Title : From tyrosine to glycine: synthesis and biological activity of potent antagonists of the purinergic P2X7 receptor.

Pub. Date : 2007 Jul 26

PMID : 17585854






1 Functional Relationships(s)
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1 The most potent P2X7 receptor antagonist identified in this study (compound 4g) contains an o-fluorine substituent on the phenylpiperazine moiety and had an IC50 of 12.1 nM. phenylpiperazine purinergic receptor P2X 7 Homo sapiens