Pub. Date : 2007 Oct
PMID : 17584971
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Cyp26b1 encodes a retinoic acid (RA) metabolizing cytochrome P450 enzyme that is expressed in embryonic tissues undergoing morphogenesis, including the testes. | Tretinoin | cytochrome P450, family 26, subfamily b, polypeptide 1 | Mus musculus |
| 2 | Cyp26b1 encodes a retinoic acid (RA) metabolizing cytochrome P450 enzyme that is expressed in embryonic tissues undergoing morphogenesis, including the testes. | Tretinoin | cytochrome P450, family 26, subfamily b, polypeptide 1 | Mus musculus |
| 3 | We have generated transgenic mice lacking Cyp26b1 and have observed increased RA levels in embryonic testes. | Tretinoin | cytochrome P450, family 26, subfamily b, polypeptide 1 | Mus musculus |
| 4 | These results provide evidence that CYP26B1 maintains low levels of RA in the developing testes that blocks entry into meiosis and acts as a survival factor to prevent apoptosis of male germ cells. | Tretinoin | cytochrome P450, family 26, subfamily b, polypeptide 1 | Mus musculus |