Title : SIRT1 deacetylase protects against neurodegeneration in models for Alzheimer's disease and amyotrophic lateral sclerosis.

Pub. Date : 2007 Jul 11

PMID : 17581637






2 Functional Relationships(s)
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Protein Name
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1 In cell-based models for AD/tauopathies and ALS, SIRT1 and resveratrol, a SIRT1-activating molecule, both promote neuronal survival. Resveratrol sirtuin 1 Mus musculus
2 In the inducible p25 transgenic mouse, a model of AD and tauopathies, resveratrol reduced neurodegeneration in the hippocampus, prevented learning impairment, and decreased the acetylation of the known SIRT1 substrates PGC-1alpha and p53. Resveratrol sirtuin 1 Mus musculus