Title : A Lys27-to-Glu27 mutation in the human insulin-like growth factor-1 prevents disulfide linked dimerization and allows secretion of BiP when expressed in yeast.

Pub. Date : 1991 Dec 9

PMID : 1756863






3 Functional Relationships(s)
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Protein Name
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1 A Lys27-to-Glu27 mutation in the human insulin-like growth factor-1 prevents disulfide linked dimerization and allows secretion of BiP when expressed in yeast. Disulfides insulin like growth factor 1 Homo sapiens
2 A majority of the IGF1-like molecules are disulfide bonded dimers. Disulfides insulin like growth factor 1 Homo sapiens
3 These results imply that by preventing ionic interactions between two IGF1 molecules, intermolecular disulfide bonds do not form in yeast, and that in the mutant there is a structural change which induces BiP, allowing its secretion. Disulfides insulin like growth factor 1 Homo sapiens