Pub. Date : 2007 Jun
PMID : 17567466
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Recent data has shown that increased LPS-stimulated phosphorylation of extracellular signal-regulated kinase pathway 1/2 (ERK1/2) is one of the important molecular targets of chronic ethanol in Kupffer cells. | Ethanol | mitogen-activated protein kinase 3 | Mus musculus |
| 2 | This increased activation of ERK1/2 after chronic ethanol is associated with increased expression of Egr-1, a transcription factor required for enhanced LPS-stimulated TNFalpha mRNA expression after chronic ethanol exposure. | Ethanol | mitogen-activated protein kinase 3 | Mus musculus |
| 3 | This increased activation of ERK1/2 after chronic ethanol is associated with increased expression of Egr-1, a transcription factor required for enhanced LPS-stimulated TNFalpha mRNA expression after chronic ethanol exposure. | Ethanol | mitogen-activated protein kinase 3 | Mus musculus |
| 4 | Here we review recent studies aimed at understanding the mechanisms by which chronic ethanol enhances the LPS-->ERK1/2-->Egr-1-->TNFalpha pathway in Kupffer cells. | Ethanol | mitogen-activated protein kinase 3 | Mus musculus |
| 5 | These studies identify a critical role for nicotinamide adenine dinucleotide phosphate (NADPH) oxidase-derived reactive oxygen species in the activation of ERK1/2 and subsequent production of TNFalpha in Kupffer cells after chronic ethanol feeding. | Ethanol | mitogen-activated protein kinase 3 | Mus musculus |