Title : The Qo site of the mitochondrial complex III is required for the transduction of hypoxic signaling via reactive oxygen species production.

Pub. Date : 2007 Jun 18

PMID : 17562787






1 Functional Relationships(s)
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1 We demonstrate that cells deficient in the complex III subunit cytochrome b, which are respiratory incompetent, increase ROS levels and stabilize the HIF-1alpha protein during hypoxia. Reactive Oxygen Species mitochondrially encoded cytochrome b Homo sapiens