Title : Core protein machinery for mammalian phosphatidylinositol 3,5-bisphosphate synthesis and turnover that regulates the progression of endosomal transport. Novel Sac phosphatase joins the ArPIKfyve-PIKfyve complex.

Pub. Date : 2007 Aug 17

PMID : 17556371






3 Functional Relationships(s)
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Protein Name
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1 This is reinforced by the structural and functional homology of yeast Vac14 and human Vac14 (ArPIKfyve), which activate yeast and mammalian PtdIns(3,5)P2-producing enzymes, Fab1 and PIKfyve, respectively. phosphatidylinositol 3,5-diphosphate Vac14p Saccharomyces cerevisiae S288C
2 In yeast, PtdIns(3,5)P2-specific phosphatase, Fig4, in association with Vac14, turns over PtdIns(3,5)P2, but whether such a mechanism operates in mammalian cells and what the identity of mammalian Fig4 may be are unknown. phosphatidylinositol 3,5-diphosphate Vac14p Saccharomyces cerevisiae S288C
3 In yeast, PtdIns(3,5)P2-specific phosphatase, Fig4, in association with Vac14, turns over PtdIns(3,5)P2, but whether such a mechanism operates in mammalian cells and what the identity of mammalian Fig4 may be are unknown. phosphatidylinositol 3,5-diphosphate Vac14p Saccharomyces cerevisiae S288C