Pub. Date : 2007 Jul 3
PMID : 17555331
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Human p53 is inhibited by glutathionylation of cysteines present in the proximal DNA-binding domain during oxidative stress. | Cysteine | tumor protein p53 | Homo sapiens |
| 2 | Mass spectrometry of GSH-modified p53 protein identified cysteines 124, 141, and 182, all present in the proximal DNA-binding domain, as the sites of glutathionylation. | Cysteine | tumor protein p53 | Homo sapiens |
| 3 | Biotinylated maleimide also reacted rapidly with Cys141, implying that this is the most reactive cysteine on the p53 surface. | Cysteine | tumor protein p53 | Homo sapiens |
| 4 | The glutathionylatable cysteines were found to exist in a negatively charged microenvironment in cellular p53. | Cysteine | tumor protein p53 | Homo sapiens |
| 5 | These results show for the first time that shielding of reactive cysteines contributes to a negative regulation for human p53 and imply that such an inactivation of the transcription factor may represent an acute defensive response with significant consequences for oncogenesis. | Cysteine | tumor protein p53 | Homo sapiens |