Title : SUN1 is required for telomere attachment to nuclear envelope and gametogenesis in mice.

Pub. Date : 2007 Jun

PMID : 17543860






2 Functional Relationships(s)
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1 Here we show that the inner nuclear membrane protein SUN1 specifically associates with telomeres between the leptotene and diplotene stages during meiotic prophase I. Disruption of Sun1 in mice prevents telomere attachment to the nuclear envelope, efficient homolog pairing, and synapsis formation in meiosis. diplotene Sad1 and UNC84 domain containing 1 Mus musculus
2 Here we show that the inner nuclear membrane protein SUN1 specifically associates with telomeres between the leptotene and diplotene stages during meiotic prophase I. Disruption of Sun1 in mice prevents telomere attachment to the nuclear envelope, efficient homolog pairing, and synapsis formation in meiosis. diplotene Sad1 and UNC84 domain containing 1 Mus musculus