Title : Anti-inflammatory effect of alpha-linolenic acid and its mode of action through the inhibition of nitric oxide production and inducible nitric oxide synthase gene expression via NF-kappaB and mitogen-activated protein kinase pathways.

Pub. Date : 2007 Jun 27

PMID : 17542608






5 Functional Relationships(s)
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1 Anti-inflammatory effect of alpha-linolenic acid and its mode of action through the inhibition of nitric oxide production and inducible nitric oxide synthase gene expression via NF-kappaB and mitogen-activated protein kinase pathways. alpha-Linolenic Acid nitric oxide synthase 2, inducible Mus musculus
2 ALA also inhibited inducible nitric oxide synthase (iNOS), cyclooxygenase-2 (COX-2), and tumor necrosis factor-alpha (TNF-alpha) gene expressions induced by LPS. alpha-Linolenic Acid nitric oxide synthase 2, inducible Mus musculus
3 ALA also inhibited inducible nitric oxide synthase (iNOS), cyclooxygenase-2 (COX-2), and tumor necrosis factor-alpha (TNF-alpha) gene expressions induced by LPS. alpha-Linolenic Acid nitric oxide synthase 2, inducible Mus musculus
4 To explore the mechanisms associated with the inhibition of iNOS gene expression by ALA, we investigated its effect on LPS-induced nuclear factor-kappaB (NF-kappaB) activation. alpha-Linolenic Acid nitric oxide synthase 2, inducible Mus musculus
5 Taken together, these results suggest that ALA downregulates inflammatory iNOS, COX-2, and TNF-alpha gene expressions through the blocking of NF-kappaB and MAPKs activations in LPS-stimulated RAW 264.7 cells, which may be the mechanistic basis for the anti-inflammatory effect of ALA. alpha-Linolenic Acid nitric oxide synthase 2, inducible Mus musculus