Title : Phospholipase D1 production of phosphatidic acid at the plasma membrane promotes exocytosis of large dense-core granules at a late stage.

Pub. Date : 2007 Jul 27

PMID : 17540765






1 Functional Relationships(s)
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1 Using a short interference RNA strategy on chromaffin and PC12 cells, we demonstrate here that phospholipase D1 is activated in secretagogue-stimulated cells and that it produces PA at the plasma membrane at the secretory granule docking sites. chromaffin phospholipase D1 Rattus norvegicus