Title : Berbamine selectively induces apoptosis of human acute promyelocytic leukemia cells via survivin-mediated pathway.

Pub. Date : 2007 May 5

PMID : 17531122






2 Functional Relationships(s)
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1 CONCLUSIONS: Berbamine induces caspase-3-dependent apoptosis of leukemia NB4 cells via survivin-mediated pathway, suggesting that berbamine may be a novel potential agent against APL with a mechanism distinct from that of all-trans retinoic acid (ATRA) and arsenic trioxide (ATO). Arsenic Trioxide caspase 3 Homo sapiens
2 CONCLUSIONS: Berbamine induces caspase-3-dependent apoptosis of leukemia NB4 cells via survivin-mediated pathway, suggesting that berbamine may be a novel potential agent against APL with a mechanism distinct from that of all-trans retinoic acid (ATRA) and arsenic trioxide (ATO). Arsenic Trioxide caspase 3 Homo sapiens