Title : [Pathophysiology and genetics of classic HFE (type 1) hemochromatosis].

Pub. Date : 2007 Sep

PMID : 17521857






2 Functional Relationships(s)
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1 Among the genetic factors, mutations of some newly identified genes may aggravate the phenotype of iron overload associated with homozygosity for the p.Cys282Tyr mutation of the HFE gene; these new genes include those of hemojuvelin (HJV), transferrin receptor 2 (TfR2), and hepcidin (HAMP). Iron hemojuvelin BMP co-receptor Homo sapiens
2 Among the genetic factors, mutations of some newly identified genes may aggravate the phenotype of iron overload associated with homozygosity for the p.Cys282Tyr mutation of the HFE gene; these new genes include those of hemojuvelin (HJV), transferrin receptor 2 (TfR2), and hepcidin (HAMP). Iron hemojuvelin BMP co-receptor Homo sapiens