Title : Structural basis for high-affinity peptide inhibition of human Pin1.

Pub. Date : 2007 May 22

PMID : 17518432






1 Functional Relationships(s)
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1 This comparative discovery suggests that a cyclic peptide polyketide bridge, like that found in FK506 and rapamycin or a similar linkage, may significantly improve the binding affinity of structure-based Pin1 inhibitors. Polyketides peptidylprolyl cis/trans isomerase, NIMA-interacting 1 Homo sapiens