Title : Constitutive and inducible thymic stromal lymphopoietin expression in human airway smooth muscle cells: role in chronic obstructive pulmonary disease.

Pub. Date : 2007 Aug

PMID : 17513456






4 Functional Relationships(s)
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1 Furthermore, combination of IL-1beta and TNF-alpha has an additive effect on TSLP release by HASMC. hasmc thymic stromal lymphopoietin Homo sapiens
2 Primary HASMC pretreated with inhibitors of p38 or p42/p44 ERK MAPK, but not phosphatidylinositol 3-kinase, showed a significant decrease in TSLP release on IL-1beta and TNF-alpha treatment. hasmc thymic stromal lymphopoietin Homo sapiens
3 Taken together, our data provide the first evidence of IL-1beta- and TNF-alpha-induced TSLP expression in HASMC via (p38, p42/p44) MAPK signaling pathways. hasmc thymic stromal lymphopoietin Homo sapiens
4 Our results raise the possibility that HASMC may play a role in COPD airway inflammation via TSLP-dependent pathway. hasmc thymic stromal lymphopoietin Homo sapiens