Title : Aspirin blocks proliferation in colon cells by inducing a G1 arrest and apoptosis through activation of the checkpoint kinase ATM.

Pub. Date : 2007 Oct

PMID : 17510082






3 Functional Relationships(s)
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1 Moreover, aspirin induced cell death mainly in cells expressing p53. Aspirin tumor protein p53 Homo sapiens
2 Aspirin induced the phosphorylation of p53 at residue Ser15 within 8 h in a caffeine-dependent manner, and also caused the activation of checkpoint kinase 2 and the cleavage of caspase 7. Aspirin tumor protein p53 Homo sapiens
3 Our results suggest that aspirin induces a G1 arrest and apoptosis by activating p53 and p21Waf1/Cip1 in an ATM-dependent way. Aspirin tumor protein p53 Homo sapiens