Title : Effects of BAY 41-2272, an activator of nitric oxide-independent site of soluble guanylate cyclase, on human NADPH oxidase system from THP-1 cells.

Pub. Date : 2007 Jul 12

PMID : 17499238






2 Functional Relationships(s)
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1 Treatment of THP-1 cells with BAY 41-2272 caused a significant increase in cGMP and cAMP levels. 3-(4-Amino-5-cyclopropylpyrimidine-2-yl)-1-(2-fluorobenzyl)-1H-pyrazolo(3,4-b)pyridine cathelicidin antimicrobial peptide Homo sapiens
2 Our findings show that BAY 41-2272 caused a significant increase on the O(2)(*-) release and gp91(phox) gene expression by THP-1 cells, and an elevation of intracellular cGMP and cAMP levels. 3-(4-Amino-5-cyclopropylpyrimidine-2-yl)-1-(2-fluorobenzyl)-1H-pyrazolo(3,4-b)pyridine cathelicidin antimicrobial peptide Homo sapiens