Title : Molecular interaction between caveolin-1 and ABCA1 on high-density lipoprotein-mediated cholesterol efflux in aortic endothelial cells.

Pub. Date : 2007 Aug 1

PMID : 17499231






6 Functional Relationships(s)
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1 Molecular interaction between caveolin-1 and ABCA1 on high-density lipoprotein-mediated cholesterol efflux in aortic endothelial cells. Cholesterol ATP binding cassette subfamily A member 1 Rattus norvegicus
2 OBJECTIVE: Caveolin-1 and ATP-binding cassette transporter A1 (ABCA1) are proteins that are involved in cellular cholesterol efflux. Cholesterol ATP binding cassette subfamily A member 1 Rattus norvegicus
3 OBJECTIVE: Caveolin-1 and ATP-binding cassette transporter A1 (ABCA1) are proteins that are involved in cellular cholesterol efflux. Cholesterol ATP binding cassette subfamily A member 1 Rattus norvegicus
4 In this study, we analyzed the relationships between caveolin-1 and ABCA1 on high-density lipoprotein (HDL)-mediated cholesterol efflux in rat aortic endothelial cells. Cholesterol ATP binding cassette subfamily A member 1 Rattus norvegicus
5 Immunoelectron microscopy demonstrated that caveolin-1 colocalized with ABCA1 in the caveolae and in the cytoplasmic vesicles; it was also found that caveolin-1 and ABCA1 colocalized with cellular cholesterol by immunofluorescence microscopy. Cholesterol ATP binding cassette subfamily A member 1 Rattus norvegicus
6 CONCLUSIONS: The molecular interaction between caveolin-1 and ABCA1 is associated with the HDL-mediated cholesterol efflux pathway in aortic endothelial cells. Cholesterol ATP binding cassette subfamily A member 1 Rattus norvegicus