Pub. Date : 2007 May 1
PMID : 17483339
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Doxorubicin treatment was found to augment the expression of the extracellular matrix (ECM) protein fibulin-1 in cultured human breast cancer cell lines and in MDA-MB-361 tumors grown in athymic mice. | Doxorubicin | fibulin 1 | Homo sapiens |
| 2 | Doxorubicin was also found to augment tumor expression of the fibulin-1-binding proteins fibronectin and laminin-1. | Doxorubicin | fibulin 1 | Homo sapiens |
| 3 | Growth of breast cancer cell lines on Matrigel, an ECM extract containing fibulin-1 and laminin-1, resulted in lower levels of doxorubicin-induced apoptosis as compared with controls. | Doxorubicin | fibulin 1 | Homo sapiens |
| 4 | Monoclonal antibodies against fibulin-1 reversed Matrigel-dependent doxorubicin resistance. | Doxorubicin | fibulin 1 | Homo sapiens |
| 5 | Furthermore, small interfering RNA-mediated suppression of fibulin-1 expression in breast cancer cells resulted in a 10-fold increase in doxorubicin sensitivity as compared with control cells. | Doxorubicin | fibulin 1 | Homo sapiens |