Pub. Date : 2007 Jul-Aug
PMID : 17482853
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | We now demonstrate that treatment of macrophages with conduritol-B-epoxide (CBE), a glucocerebrosidase inhibitor, results in elevated activity of CTP:phosphocholine cytidylyltransferase (CCT), the rate-limiting enzyme in the pathway of PC biosynthesis. | Phosphatidylcholines | phosphate cytidylyltransferase 1, choline, alpha isoform | Mus musculus |
| 2 | We now demonstrate that treatment of macrophages with conduritol-B-epoxide (CBE), a glucocerebrosidase inhibitor, results in elevated activity of CTP:phosphocholine cytidylyltransferase (CCT), the rate-limiting enzyme in the pathway of PC biosynthesis. | Phosphatidylcholines | phosphate cytidylyltransferase 1, choline, alpha isoform | Mus musculus |
| 3 | Together, these results suggest that the increase in PC biosynthesis is mediated via CCTalpha, and suggests a possible role for macrophage CCTalpha in Gaucher disease pathology. | Phosphatidylcholines | phosphate cytidylyltransferase 1, choline, alpha isoform | Mus musculus |
| 4 | Together, these results suggest that the increase in PC biosynthesis is mediated via CCTalpha, and suggests a possible role for macrophage CCTalpha in Gaucher disease pathology. | Phosphatidylcholines | phosphate cytidylyltransferase 1, choline, alpha isoform | Mus musculus |