Title : Guggulsterone inhibits tumor cell proliferation, induces S-phase arrest, and promotes apoptosis through activation of c-Jun N-terminal kinase, suppression of Akt pathway, and downregulation of antiapoptotic gene products.

Pub. Date : 2007 Jun 30

PMID : 17475222






3 Functional Relationships(s)
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1 Guggulsterone inhibits tumor cell proliferation, induces S-phase arrest, and promotes apoptosis through activation of c-Jun N-terminal kinase, suppression of Akt pathway, and downregulation of antiapoptotic gene products. pregna-4,17-diene-3,16-dione AKT serine/threonine kinase 1 Homo sapiens
2 The apoptotic effects of guggulsterone were preceded by activation of JNK and downregulation of Akt activity. pregna-4,17-diene-3,16-dione AKT serine/threonine kinase 1 Homo sapiens
3 Overall, our results indicate that guggulsterone can inhibit cell proliferation and induce apoptosis through the activation of JNK, suppression of Akt, and downregulation of antiapoptotic protein expression. pregna-4,17-diene-3,16-dione AKT serine/threonine kinase 1 Homo sapiens