Title : The folate receptor alpha is frequently overexpressed in osteosarcoma samples and plays a role in the uptake of the physiologic substrate 5-methyltetrahydrofolate.

Pub. Date : 2007 May 1

PMID : 17473184






1 Functional Relationships(s)
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1 Among the transfected 143B sublines, only the 143B-FR alpha was able to uptake 5-methyltetrahydrofolate when the extracellular concentration was reduced to 2 nmol/L, which conferred a growth advantage in physiologic folate concentrations compared with vector-only-transfected cells. Folic Acid rabaptin, RAB GTPase binding effector protein 2 Homo sapiens