Title : Glycine-induced long-term synaptic potentiation is mediated by the glycine transporter GLYT1.

Pub. Date : 2007 Jun

PMID : 17462677






4 Functional Relationships(s)
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1 Glycine-induced long-term synaptic potentiation is mediated by the glycine transporter GLYT1. Glycine solute carrier family 6 member 9 Rattus norvegicus
2 In contrast, LTP-GLY is partially or totally blocked with the antagonists of glycine transporter GLYT1, sarcosine or ALX-5407, respectively. Glycine solute carrier family 6 member 9 Rattus norvegicus
3 These results indicate that LTP-GLY requires the activation of GLYT1, a glycine transporter co-localized and associated to NMDA receptors. Glycine solute carrier family 6 member 9 Rattus norvegicus
4 In addition, the fact that NMDA receptor inhibition increases LTP-GLY magnitude, opens the possibility that these receptors could have a negative control on GLYT1 activity. Glycine solute carrier family 6 member 9 Rattus norvegicus