Pub. Date : 2007 Jun
PMID : 17459751
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The purpose of the studies presented here was to describe some of the preclinical development of idursulfase using the I2S knock-out mouse model of MPS II designed to study the effect of dose and various dosing regimens of idursulfase on urine and tissue GAG levels. | Glycosaminoglycans | iduronate 2-sulfatase | Homo sapiens |
| 2 | The purpose of the studies presented here was to describe some of the preclinical development of idursulfase using the I2S knock-out mouse model of MPS II designed to study the effect of dose and various dosing regimens of idursulfase on urine and tissue GAG levels. | Glycosaminoglycans | iduronate 2-sulfatase | Homo sapiens |
| 3 | Results showed that idursulfase, at several doses and at several dosing frequencies, caused a reduction in tissue and urine GAG levels in a dose-dependent manner. | Glycosaminoglycans | iduronate 2-sulfatase | Homo sapiens |
| 4 | These studies also demonstrated that after IV administration, idursulfase is biologically active in the IdS-KO mouse model and is transported to key target tissues, reaching the lysosomes in an active form, and degrading the accumulated GAG. | Glycosaminoglycans | iduronate 2-sulfatase | Homo sapiens |