Title : Adult mice with reduced Nurr1 expression: an animal model for schizophrenia.

Pub. Date : 2007 Aug

PMID : 17457314






3 Functional Relationships(s)
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1 In addition, Nurr1 (+/-) male mice displayed a reduced dopamine turnover in the striatum and an enhanced dopamine turnover in the prefrontal cortex, while female mice showed an opposite pattern. Dopamine nuclear receptor subfamily 4, group A, member 2 Mus musculus
2 In addition, Nurr1 (+/-) male mice displayed a reduced dopamine turnover in the striatum and an enhanced dopamine turnover in the prefrontal cortex, while female mice showed an opposite pattern. Dopamine nuclear receptor subfamily 4, group A, member 2 Mus musculus
3 These results show that Nurr1 (+/-) mice display a pattern of behaviors indicative of potential relevance for symptoms of schizophrenia combined with a gender-specific abnormal dopamine transmission in the striatum and prefrontal cortex, respectively. Dopamine nuclear receptor subfamily 4, group A, member 2 Mus musculus