Title : Analysis of a Shc family adaptor protein, ShcD/Shc4, that associates with muscle-specific kinase.

Pub. Date : 2007 Jul

PMID : 17452444






2 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 Activation of MuSK upon agrin binding at the neuromuscular junction (NMJ) induces clustering and tyrosine phosphorylation of acetylcholine receptors (AChRs) required for synaptic transmission. Tyrosine agrin Homo sapiens
2 ShcD is coexpressed with MuSK in the postsynaptic region of the NMJ, and in cultured myotubes stimulated with agrin, expression of ShcD appears to be important for early tyrosine phosphorylation of the AChR. Tyrosine agrin Homo sapiens