Pub. Date : 2007 May
PMID : 17446929
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The p63/p73 network mediates chemosensitivity to cisplatin in a biologically defined subset of primary breast cancers. | Cisplatin | tumor protein p63 | Homo sapiens |
| 2 | Here we demonstrated that the p53 family member p63 controls a pathway for p73-dependent cisplatin sensitivity specific to these "triple-negative" tumors. | Cisplatin | tumor protein p63 | Homo sapiens |
| 3 | These findings define p63 as a survival factor in a subset of breast cancers; furthermore, they provide what we believe to be a novel mechanism for cisplatin sensitivity in these triple-negative cancers, and they suggest that such cancers may share the cisplatin sensitivity of BRCA1-associated tumors. | Cisplatin | tumor protein p63 | Homo sapiens |
| 4 | These findings define p63 as a survival factor in a subset of breast cancers; furthermore, they provide what we believe to be a novel mechanism for cisplatin sensitivity in these triple-negative cancers, and they suggest that such cancers may share the cisplatin sensitivity of BRCA1-associated tumors. | Cisplatin | tumor protein p63 | Homo sapiens |